A Role of Sphingosine Kinase 1 in head & neck carcinogenesis
نویسندگان
چکیده
Authors’ Affiliations: Departments of 1 Hematology/Oncology, Medicine, 2 Pathology & Laboratory Medicine, 3 Biochemistry and Molecular Biology, 4 Internal Medicine, and 5 Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, 6 VA Staff Physician, Research Service, Ralph H. Johnson VAMC, Charleston, South Carolina, and 7 University of Hawaii Cancer Center, Honolulu, Hawaii Grant Support: NIH grants P01CA097132 (J. Bielawski, Y.A. Hannun, L.M. Obeid, B. Ogretmen, and T. Kawamori), R01CA124687 (T. Kawamori), R01DE016572 (B. Ogretmen), and C06RR015455 (Research Facilities Support grant). A MERIT Award by the Office of Research and Development, Department of Veterans Affairs, Ralph H. Johnson VA Medical Center, Charleston, South Carolina (L.M. Obeid). Requests for reprints: Toshihiko Kawamori, MD, Ph.D., University of Hawaii Cancer Center, 651 Ilalo Street, BSB 222H, Honolulu, HI 96813, Phone: 808-441-7718, Fax: 808-587-0742, Email: [email protected] Running Title: SphK1 in HNSCC development
منابع مشابه
A role of sphingosine kinase 1 in head and neck carcinogenesis.
It is important to identify novel and effective targets for cancer prevention and therapy against head and neck squamous cell carcinoma (HNSCC), one of the most lethal cancers. Accumulating evidence suggests that the bioactive sphingolipids, such as sphingosine-1-phosphate (S1P) and its generating enzyme, sphingosine kinase 1 (SphK1) play pivotal roles in several important biological functions ...
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Sphingosine kinase-1 (SPHK1) modulates the proliferation, apoptosis and differentiation of keratinocytes through the regulation of ceramide and sphingosine-1-phosphate levels. However, studies on the expression of SPHK1 in human head and neck squamous cell carcinoma (HNSCC) specimens are lacking. Therefore, the aim of the present work was to evaluate SPHK1 expression in human primary HNSCCs and...
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Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer type, with an annual incidence of approximately half a million people worldwide. It has a high recurrence rate and an extremely low survival rate. This is due to limited availability of effective therapies to reduce the rate of recurrence, resulting in high morbidity and mortality of patients with advanced stages of...
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Head and neck squamous cell carcinoma (HNSCC) has a high reoccurrence rate and an extremely low survival rate. There is limited availability of effective therapies to reduce the rate of recurrence, resulting in high morbidity and mortality of advanced cases. Late presentation, delay in detection of lesions, and a high rate of metastasis make HNSCC a devastating disease. This review offers insig...
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